FRAT®

Uncovering Folate Transport Issues
FRAT®: A blood test that screens for folate receptor autoantibodies, indicating a potential impediment in folate transport to the brain

FRAT® (Folate Receptor Autoantibody Test) measures the presence of autoantibodies against the folate receptor alpha (FRa) protein. Folate receptor autoantibodies can interfere with folate (vitamin B9) transport into the brain, potentially leading to neurological symptoms and developmental delays.

If FRAT® detects autoantibodies, a healthcare professional can discuss treatment options. This may involve using alternative folate forms that bypass the blocked transport system or making dietary adjustments. Please consult your physician for information and guidance.

Folate receptor autoantibodies have been linked to neurodevelopmental, neuropsychiatric and neurodegenerative conditions such as:
  • Cerebral Folate Deficiency Syndrome
  • Autism Spectrum Disorders
  • Neural Tube Defects
  • Depression
  • Schizophrenia
Who Should Consider FRAT®?

FRAT® is recommended for children experiencing various neurodevelopmental, neuropsychiatric or neurodegenerative symptoms. If a child exhibits any of the following conditions, FRAT® may provide valuable insights:

  • Developmental Delays: Children who fail to meet expected milestones in areas such as speech, motor skills, or social interaction.
  • Autism Spectrum Disorder: Children diagnosed with autism or showing signs of autism-related behaviors and communication difficulties.
  • Seizures: Children experiencing recurrent, unprovoked seizures or epilepsy.
  • Abnormal Movements: Children displaying involuntary, repetitive, or unusual movements, such as tics or dystonia.
  • Cognitive Impairment: Children with difficulties in learning, memory, attention, or problem-solving skills.
  • Behavioral Issues: Children exhibiting persistent, disruptive, or age-inappropriate behaviors, such as aggression, impulsivity, or anxiety.
  • Neurological Symptoms of Unknown Cause: Children with unexplained neurological symptoms that do not fit a specific diagnosis or have not responded to previous treatments.
Neurodevelopmental, Neuropsychiatric and Neurodegenerative Disorders